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Specifically, glutathione plays an indispensable role in the innate immune response, the frontline defense against invading pathogens

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When adriamycin induces aging in ATDC5 chondrocytes, catalpol delays the progression of knee osteoarthritis by promoting apoptosis and reducing aging-related phenotypes such as P21 and P53, as well as MMP13 and IL-6 (Jia et al., 2024)

As part of diisopropylamine dichloroacetate, dichloroacetate has also been shown to be directly harmful to humans and animals (211), as well as mutagenic in the Ames mutagenicity test (212)